Product Description: Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.
Applications: COVID-19-immunoregulation
Formula: C21H18ClNO4
Citations: Cytokine. 2024 Jul 26:182:156717./Harvard Medical School LINCS LIBRARY/Heliyon. 2024 Jul 28;10(15):e35368./J Headache Pain. 2022 Mar 8;23(1):35./Phytother Res. 2023 Jul 4./Research Square Preprint. 2020 Oct./Sci Rep. 2017 Aug 23;7(1):9201./Biochem Biophys Res Commun. 2024 Oct 29:739:150914./Cancer Cell Int. 2023 Jun 17;23(1):117./Cell Commun Signal. 2021 Oct 11;19(1):103./FASEB J. 2019 Dec;33(12):13644-13659./Fishes. 2022, 7(5), 229./Front Pharmacol. 13 May 2021./Front Physiol. 2021 Oct 28;12:770430./Planta Med. 2024 Jun;90(7-08):523-533.
References: [1]Li W, et al. Effect of Chelerythrine Against Endotoxic Shock in Mice and Its Modulation of Inflammatory Mediators in Peritoneal Macrophages Through the Modulation of Mitogen-Activated Protein Kinase (MAPK) Pathway. Inflammation. 2012 Jul 24./[2]Pencikova K, et al. Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line. Phytomedicine. 2012 Jul 15;19(10):890-5. Epub 2012 May 14./[3]Chen XM, et al. Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines. Oncol Lett. 2016 Jun;11(6):3917-3924/[4]Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9./[5]Chan SL, et al.Identification of chelerythrine as an inhibitor of BclXL function.J Biol Chem. 2003 Jun 6;278(23):20453-6./[6]Tang ZH, et al.Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells.Redox Biol. 2017 Aug;12:367-376.
CAS Number: 3895-92-9
Molecular Weight: 383.82
Compound Purity: 99.42
Research Area: Cancer; Metabolic Disease; Inflammation/Immunology
Solubility: DMSO : 4.35 mg/mL (ultrasonic)
Target: Apoptosis;Autophagy;Bcl-2 Family;PKC
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