Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 4-[4,6-dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]-benzoic acid
Purity: ≥98%
Formula Markup: C25H19N3O4
Formula Weight: 425.4
CAS Number: 834903-43-4
Notes: CID-16020046 is a GPR55 inverse agonist that antagonizes GPR55 constitutive activity with an IC50 value of 15 μM.{29659} It inhibits GPR55-mediated ERK1/2 phosphorylation, LPI-induced Ca2+ signaling (IC50 = 0.21 μM in HEK-GPR55 cells), and GPR55-mediated transcription factor activation.{29659} It does not affect ERK1/2 phosphorylation or transcription factor activation in CB receptor expressing cells and demonstrates weak activity against a broad spectrum of other GPCRs, ion channels, kinases, and nuclear receptors.{29659} This compound has been shown to block GPR55-mediated endothelial wound healing and reverse LPI-inhibited platelet aggregation.{29659}
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