Product Description: Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
Applications: COVID-19-immunoregulation
Formula: C22H23ClF3N
Citations: Adv Mater. 2024 Jun;36(24):e2311760./Cell Rep Methods. 2023 Oct 23;3(10):100599./iScience. 2023 Mar./Patent. US20230147129A1./Acta Physiol. 2023 Jan 6;e13926./Calcif Tissue Int. 2023 Feb 8./Cell Biol Toxicol. 2022 May 30./Gen Comp Endocrinol. 2018 Oct 1;267:1-8./J Agric Food Chem. 2021 Nov 8./J Biol Chem. 2016 Oct 28;291(44):23126-23135./J Food Sci. 2018 Sep;83(9):2394-2401./J Med Chem. 2015 Apr 9;58(7):2958-66. /Oxid Med Cell Longev. 2017;2017:3869561./Oxid Med Cell Longev. 2021 Jan 12;2021:3010548.
References: [1]Colloton M, et al. Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int. 2005 Feb;67(2):467-76./[2]D.A. Bushinsky, et al. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006 May;69(9):1586-92.
CAS Number: 364782-34-3
Molecular Weight: 393.87
Compound Purity: 99.99
Research Area: Cardiovascular Disease; Cancer
Solubility: DMSO : ≥ 50 mg/mL/H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target: CaSR;Endogenous Metabolite
English
Deutsch
