Product Description: Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro[1][2][3].
Applications: COVID-19-anti-virus
Formula: C20H25ClN2OS
References: [1]Chen L, et al. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J Virol. 2005 Jun;79(11):7095-103./[2]Hernekamp JF, et al. Cinanserin reduces plasma extravasation after burn plasma transfer in rats. Burns. 2013 Sep;39(6):1226-33./[3] Leysen JE, et al. Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors. Life Sci. 1981 Mar 2;28(9):1015-22.
CAS Number: 54-84-2
Molecular Weight: 376.94
Compound Purity: 99.48
Research Area: Infection; Inflammation/Immunology
Solubility: DMSO : 125 mg/mL (ultrasonic)/H2O : 100 mg/mL (ultrasonic)
Target: 5-HT Receptor;Influenza Virus
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