Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1,3,8-trihydroxy-6-(hydroxymethyl)-9,10-anthracenedione
Purity: ≥98%
Formula Markup: C15H10O6
Formula Weight: 286.239
CAS Number: 481-73-2
Notes: A polyketide anthraquinone with antibacterial and anti-inflammatory activities; active against E. coli from 31.25-500 µg/ml, P. aeruginosa from 62.5-500 µg/ml, and B. subtilis at 250 and 500 µg/ml; reduces LPS-induced NO production and LPS-induced increases in TNF-α and IL-6 levels in RAW 264.7 cells at 25 µg/ml; reduces PGD2 production and COX-2 levels in mouse SCF-, IL-10-, and LPS-stimulated primary mouse BMMCs at 10 and 20 µM; inhibits SCF-, IL-10-, and LPS-induced increases in NF-κB p65 nuclear translocation in primary mouse BMMCs at 10 and 20 µM