Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[(1S)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide, monohydrochloride
Purity: ≥95%
Formula Markup: C14H19ClN4O2 / HCl
Formula Weight: 347.23976
CAS Number: 1373232-26-8
Notes: Cl-Amidine is an irreversible inhibitor of protein arginine deiminases (PADs; IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively).{18132,19982,36047} It is cytotoxic to HL-60, MCF-7, and HT-29 cancer cells (IC50s = 0.25, 0.05, and 1 μM, respectively).{18529} Cl-amidine (50 mg/kg) reduces ex vivo extracellular neutrophil extracellular trap (NET) formation and increases survival in a mouse model of sepsis induced by cecal ligation and puncture (CLP).{58272} It also decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies in a mouse model of collagen-induced arthritis in a dose-dependent manner.{19981}
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