Clone: 2A11
Specificity: Recognizes murine beta-glucan receptor, also known as Dectin-1. Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells. As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens. Recent work has shown that Dectin-1 may stimulate reactive oxygen production in macrophages via the protein tyrosine kinase known as Syk. Inhibits the binding of zymosan to macrophages via the beta-glucan receptor. The low endotoxin version is recommended for functional studies.
Antibody Modification: FITC
Presentation: PBS, 0.09% Sodium Azide, 1% BSA
Immunogen: Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1.
Gene: CLEC7A / Dectin 1
Description: Dectin 1 antibody LS-C188262 is an FITC-conjugated rat monoclonal antibody to mouse Dectin 1 (CLEC7A). Validated for Flow.
Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Synonyms: CLEC7A, BGR, CANDF4, CLECSF12, Dectin-1, DC-associated C-type lectin 1, DECTIN1, HDectin-1, Beta-glucan receptor, Lectin-like receptor 1, CD369
Recommended Storage: Store at 4°C. Do not freeze. Store undiluted. Protect from light. Microcentrifugation recommended if solution contains precipitate.
Concentration: 0.1 mg/ml
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