Target Synonym: coagulation factor;TFQTL;F3;CD142;TF;TFA;CD142 antigen;coagulation factor 3;Coagulation factor III;Coagulation factor III (thromboplastin tissue factor);FIII;FLJ17960;HEL-S-71p;PRO1557;PRO2086;TFQTL1;Thromboplastin;Tissue factor;transferrin;Tissue Factor (TF);Factor III
Background: This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.
Immunogen: Recombinant Human F3 / Tissue factor / CD142 protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: ICC/IF 1:20-1:100;FCM 1:25-1:100;
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