Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (3R,6R,9S)-12-methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl-d8)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid, 5-thiazolylmethyl ester
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C40H45D8N7O5S2
Formula Weight: 784.07348
CAS Number: 2699607-48-0
Notes: Cobicistat-d8 is intended for use as an internal standard for the quantification of cobicistat (Item No. 23433) by GC- or LC-MS. Cobicistat is an inhibitor of the cytochrome P450 (CYP) isomer CYP3A (IC50s = 30-285 nM for CYP3A metabolism of various HIV protease inhibitors).{41224} It is selective for CYP3A over other CYP isomers (IC50 = >25 μM for CYP1A2, 2C8, 2C9, and 2C19). Cobicistat does not inhibit HIV-1 protease (IC50 = >30 μM) or affect HIV replication in MT-2 cells (EC50 = >30 μM). Formulations containing cobicistat have been used to slow the metabolism of concomitantly administered protease inhibitors in the treatment of HIV.{41225}
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