COH29, CAS 1190932-38-7

Product Description: COH29 (RNR Inhibitor COH29) is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity. COH29 inhibits α and β subunit of RNR with IC50s of 16 μM.

Applications: Cancer-programmed cell death

Formula: C22H16N2O5S

References: [1]Zhou B, et al. A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance.Cancer Res. 2013 Nov 1;73(21):6484-93./[2]Chen MC, et al. The Novel Ribonucleotide Reductase Inhibitor COH29 Inhibits DNA Repair In Vitro. Mol Pharmacol. 2015 Jun;87(6):996-1005.

CAS Number: 1190932-38-7

Molecular Weight: 420.44

Compound Purity: 98.76

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: DNA/RNA Synthesis

• SKU: MEXHY-19931-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-19931-25
• Package Unit: 25 mg
• Quantity Unit: STK