Product Description: Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.
Applications: COVID-19-immunoregulation
Formula: C52H98N16O13.2.5H2O4S
Citations: Adv Sci (Weinh). 2020 Jul 21;7(17):2001374./Animal Diseases. 02 November 2021./Clin Microbiol Infect. 2020 Sep;26(9):1264-1265./Hum Exp Toxicol. 2021 Apr 22;9603271211010906./J Antibiot (Tokyo). 2019 Aug;72(8):600-604. /Nat Commun. 2022 Mar 2;13(1):1116./Nat Commun. 2024 Sep 10;15(1):7914./Patent. US20200101105A1./Animal Diseases. 2024 Apr 3./Cell Host Microbe. 2024 May 13:S1931-3128(24)00137-9./Emerg Microbes Infect. 2024 Dec;13(1):2321981./Microorganisms. 2024 Mar 13, 12(3), 575./Vet Microbiol. 2024 May, 292, 110046.
References: [1]Hancock RE et al. Peptide antibiotics. Antimicrob Agents Chemother. 1999 Jun;43(6):1317-23./[2]Li J, et al. In vitro pharmacodynamic properties of colistin and colistin methanesulfonate againstPseudomonas aeruginosa isolates from patients with cystic fibrosis. Antimicrob Agents Chemother. 2001 Mar;45(3):781-5./[3]W S Yapa S, et al. Population pharmacokinetics of colistin methanesulfonate in rats: achieving sustained lung concentrations of colistin for targeting respiratory infections. Antimicrob Agents Chemother. 2013 Oct;57(10):5087-95./[4]Fleury MA, et al. Impact of two different colistin dosing strategies on healthy piglet fecal microbiota. Res Vet Sci. 2016 Aug;107:152-60.
CAS Number: 1264-72-8
Molecular Weight: 1400.64
Compound Purity: 98.0
Research Area: Infection
Solubility: DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)/H2O : 50 mg/mL (ultrasonic)
Target: Antibiotic;Autophagy;Bacterial
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