Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-phenol, dihydrogen phosphate, disodium salt
Purity: ≥98%
Formula Markup: C18H19O8P / 2Na
Formula Weight: 440.3
CAS Number: 168555-66-6
Notes: Combretastatin A4 (CA4) is a potent inhibitor of tubulin polymerization that displays strong inhibitory activity on tumor cell growth. Combretastatin-A-4-3’-O-phosphate (CA4P) is a CA4 prodrug that inhibits tumor growth in several cell lines including P-388 (leukemia), SK-N-SH (neuroblast), BXPC-3 (pancreas), NCI-H460 (lung), and DU-145 (prostate) with ED50 values of 0.0029, 0.00025, 0.23, 0.00035, and 0.00072 µg/ml, respectively.{13212} CA4P specifically targets the tumor vasculature. In a rat model of carcinosarcoma, CA4P delivered intraperitoneally at a dose of 100 mg/kg effectively disrupts tumor blood flow within six hours after administration without significantly affecting normal tissues.{15817}
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