Product Description: Conoidin A is a cell permeable inhibitor of?T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. Conoidin A covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. Conoidin A also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII)[1][2]. Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease[3].
Applications: COVID-19-immunoregulation
Formula: C10H8Br2N2O2
References: [1]Jeralyn D Haraldsen, et al. IDENTIFICATION OF CONOIDIN A AS A COVALENT INHIBITOR OF PEROXIREDOXIN II. Org Biomol Chem. 2009;7:3040-3048./[2]Gu Liu, et al. Optimisation of conoidin A, a peroxiredoxin inhibitor. ChemMedChem. 2010 Jan;5(1):41-5./[3]Bo Wei, et al. Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II. Br J Pharmacol
CAS Number: 18080-67-6
Molecular Weight: 347.99
Compound Purity: 98.03
Research Area: Infection; Neurological Disease; Cardiovascular Disease
Solubility: DMSO : 14.29 mg/mL (ultrasonic)
Target: Parasite
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