Autoimmune Diagnostics

Rheumatic Diseases

More than 400 different diseases are grouped under the term rheumatic. Due to the enormous variety of symptoms and the course of those diseases that are classified as "rheumatic diseases", they can be divided into the following main groups:

• Collagenoses (Connective Tissue Disorder)
• Rheumatoid Arthritis - The Staged Multimarker Concept

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Vasculitis

Wegener's granulomatosis (WG) is very closely related to the anti-neutrophil cytoplasmic antibodies (ANCA). Especially those which are directed against proteinase 3 (PR3). ANCAs directed against myeloperoxidase (MPO) are associated with microscopic polyangiitis (MPA) and Churg-Strauss syndrome.

PR3-ANCA-associated vasculitis differs from the MPO-ANCA associated vasculitis by the occurrence of granulomatous inflammation.

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Autoimmune liver disease

In AIH (autoimmune hepatitis) patients, anti-nuclear antibodies (ANA) are detectable in 98% of cases, either alone or in combination with other antibodies such as:

• Smooth muscles (SMA) 
• Actin epitopes 
• Liver-kidney microsomes (anti-LKM1) 
• Liver-pancreas-specific or soluble liver antigen (Anti-LP/SLA).
  
  

The increased IgG level in the serum is also typical for AIH.

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Antiphospholipid Syndrome

The antiphospholipid syndrome (APS) is an autoimmune disease which is caused by a number of possible clinical, hematological and serological manifestations, such as venous and/or arterial thrombosis, miscarriage, premature birth based on (pre) eclampsia or placental insufficiency.

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Immune Complexes

The determination of immune complexes is used in various areas:

• The assessment of the severity of a disease
• Evaluation of the therapy progress
• Diagnosis of those diseases in which the pathological CIC level has a clinical implication for the therapy
• Elevated levels of circulating immune complexes can be found in various diagnostic areas
• Rheumatic Disease spectrum of diseases
• Chronic polyarthritis (classification criterion for RA (ACR, 1987))
• SLE
• Sjogren's Syndrome
• MCTD
• Panarteritis nodosa
• Felty Syndrome
• Behcet's Syndrome
• Churg-Strauss Syndrome
• Bechterew (see HLA-B-27)
• M. Reiter

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Thyroid Diagnostics

Advantages at a glance

• Complete range for laboratory diagnosis of autoimmune thyroid diseases
• Up-to-date diagnosis of Graves disease using anti-TSH receptor determination
• Calibration in international WHO units
  
  

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Gastrointestinal Diseases

Celiac Disease

• Chronic Inflammatory Bowel Disease (IBD)
• Ulcerative colitis and Morbus Crohn
• Pernicious anemia and autoimmune gastritis
  
  

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Cardiology

• The company IMTEC offers ELISA for the detection of "high sensitive" C-reactive protein and an ELISA for the detection of oxLDL (oxidized low density lipoproteins).
• For immunofluorescence we offer heart antibodies (primates / rats) from BIOS and IMMCO.
  
  

For the complete product range from Immco Diagnostics and Imtec/Human please visit our webshop.