Product Description: CP 122721 hydrochloride is a potent, non-peptide and selective nonpeptide neurokinin NK1 antagonist, with a pIC50 of 9.8 for human NK1 receptor expressed in IM-9 cells. CP 122721 hydrochloride exhibits anxiolytic and antidepressant-like effects[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C20H25Cl2F3N2O2
References: [1]McLean S, et, al. Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor. J Pharmacol Exp Ther. 1996 May;277(2):900-8./[2]Kamel A, et, al. Metabolism and excretion of CP-122,721, a non-peptide antagonist of the neurokinin NK1 receptor, in dogs: identification of the novel cleaved product 5-trifluoromethoxy salicylic acid in plasma. Xenobiotica. 2007 May;37(5):559-78.
CAS Number: 145877-52-7
Molecular Weight: 453.33
Research Area: Neurological Disease
Solubility: 10 mM in DMSO
Target: Neurokinin Receptor
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