CP 466,722, CAS 1080622-86-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1-(6,7-dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine

Purity: ≥98%

Formula Markup: C17H15N7O2

Formula Weight: 349.4

CAS Number: 1080622-86-1

Notes: CP 466,722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase that inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of the ATM targets SMC1, Chk2, and p53 in HeLa cells when used at a concentration of 10 μM.{36744} It is selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively. CP 466,722 decreases cell survival in response to ionizing radiation in HeLa cells. It is also cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC50s = 16.92 and 12.78 μM, respectively).{36744}

• SKU: CAY25417-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 25417-1
• Package Unit: 1 mg
• Quantity Unit: STK