CPHPC, CAS 224624-80-0

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1,1'-(1,6-dioxo-1,6-hexanediyl)bis-D-proline

Purity: ≥95%

Formula Markup: C16H24N2O6

Formula Weight: 340.4

CAS Number: 224624-80-0

Notes: CPHPC is an inhibitor of the protein-protein interaction between serum amyloid P (SAP) and amyloid fibrils (IC50 = 0.9 µM).{10002} It also crosslinks with pentameric SAP in the plasma to form a decameric complex, which is eliminated via hepatic clearance. As plasma and amyloid deposits of SAP exist in a dynamic equilibrium, CPHPC induces the dissociation of SAP from tissue amyloid deposits, leading to its redistribution into the plasma, where it is eliminated. DPHC (1 mg/ml in the drinking water) reduces serum human SAP levels in a transgenic mouse model of amyloidosis.

• SKU: CAY75500-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 75500-5
• Package Unit: 5 mg
• Quantity Unit: STK