CPI-1205, CAS 1621862-70-1

Shelf life (days): 730

Info: A potent EZH2 inhibitor (IC50s = 2 and 3 nM for wild-type and the constitutively active EZH2 Y641N catalytic mutant, respectively); inhibits EZH1 (IC50 = 52 nM); decreases levels of H2K27me3 in HeLa cells (EC50 = 32 nM); reduces tumor size and H3K27me3 levels in a KARPAS-422 B cell lymphoma xenograft mouse model (160 mg/kg)

Formulation: A crystalline solid

Formal Name: N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-2-methyl-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]ethyl]-1H-indole-3-carboxamide

Purity: ≥98%

Formula Markup: C27H33F3N4O3

Formula Weight: 518.6

CAS Number: 1621862-70-1

• SKU: CAY22962-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22962-10
• Package Unit: 10 mg
• Quantity Unit: STK