Target: Cpn10
Conjugate: FITC
Product Type: Polyclonal
Immunogen: Human Cpn10 peptide AA 91-101
Swiss-Prot: P61604
Purification: Protein A Purified
Storage Buffer: 640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS
Concentration: 1 mg/ml
Specificity: Detects ~ 10kDa.
Cellular Localization: Mitochondrion / Mitochondrion Matrix
Scientific Background: Chaperonin 10, otherwise known as Cpn10, (groES in E.coli) make up a family of small heart shock proteins with an approximate molecular mass of 10kDa (HSP10s). Cpn10 acts as a co-chaperone and interacts with the HSP60 family to promote proper folding of polypeptides. Cpn10 and Cpn60 both exhibit sevenfold axis of symmetry and function as a team in the protein folding and assembly process (1). Cpn10 has been located in human platelets, but is also present in human maternal serum (2, 3). It has been reported that human Cpn10 is identical with early pregnancy factor, which is involved in control over cell growth and development. This identification suggest that Cpn10 may act like a hormone in stressful situations such as pregnancy (4).
References: 1. Velez-Granell C.S., et al. (1994) J of Cell Science. 107(3): 539-549.2. Morton H., Hegh V., and Clunie G.J.A. (1974) Nature (London) 249: 459-460.3. Cavanagh A.C., and Morton H. (1994) Eur. J. Biochem. 222: 551-560.4. Minto M., et al. (1998) Molecular Cell Research. 1403 (2): 151-157.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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