Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2,3-dihydro-2-oxo-adenosine
Purity: ≥95%
Formula Markup: C10H13N5O5
Formula Weight: 283.24092
CAS Number: 1818-71-9
Notes: Crotonoside is a guanosine analog originally isolated from C. tiglium that has diverse biological activities.{47658,47659,47660} It is cytotoxic to P338, L5178Y, Sp2/O, HL-60, and Raji cells in vitro (EC50s = 21, 370, 120, 70, and 400 μM, respectively).{47658} Crotonoside (48 mg/kg per day for 12 days) reduces tumor growth by 60% in S-180 sarcoma and Ehrlich carcinoma solid tumor mouse models. It has been used as an internal standard for the semi-quantitative analysis and comparison of RNA metabolites in MCF-7 breast cancer cells and MCF-10A mammary epithelial cells.{47661} Crotonoside decreases the force and rate of contraction in isolated guinea pig atria (EC50s = 2.8 and 17.8 μM, respectively) and reduces carotid blood pressure in anesthetized cats when administered intravenously at a dose of 0.5 μmol/kg.{47659,47660}
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