CU CPT 22, CAS 1416324-85-0

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 3,4,6-trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid, hexyl ester

Purity: ≥98%

Formula Markup: C19H22O7

Formula Weight: 362.4

CAS Number: 1416324-85-0

Notes: CU CPT 22 is an antagonist of toll-like receptor 1 (TLR1) and TLR2 heterodimers (TLR1/TLR2; Ki = 0.41 µM).{48799} It inhibits nitric oxide (NO) production induced by the TLR2 agonist Pam3CSK4 (Item No. 24126) in RAW 264.7 cells (IC50 = 0.58 µM). It is selective for TLR1/TLR2 over TLR2/TLR6 and TLR3, -4, and -7 homodimers, as well as 10 kinases at 0.5 µM. CU CPT 22 (8 µM) inhibits Pam3CSK4-induced release of TNF-α and IL-1β in RAW 264.7 cells by 60 and 95%, respectively.

• SKU: CAY15244-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 15244-5
• Package Unit: 5 mg
• Quantity Unit: STK