CUR 61414, CAS 334998-36-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[(3S,5S)-1-(1,3-benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethyl-butanamide

Purity: ≥98%

Formula Markup: C31H42N4O5

Formula Weight: 550.7

CAS Number: 334998-36-6

Notes: CUR 61414 is a potent inhibitor of hedgehog-induced cellular activity (IC50 = 100-200 nM).{24330,24331} It binds directly with the pathway activator Smoothened (Ki = 44 nM).{20488} CUR 61414 blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of basaloid lesions triggered by ultraviolet light in mouse skin.{24330,24332}

• SKU: CAY14931-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 14931-5
• Package Unit: 5 mg
• Quantity Unit: STK