Product Description: CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively[1].
Applications: Cancer-Kinase/protease
Formula: C26H27Cl2N3O4
References: [1]Mustapha Haddach, Jerome Michaux, Michael K, Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor. ACS Med. Chem. Lett., 2012, 3 (2), pp 135-139/[2]Padmanabhan A, Gosc EB, Bieberich CJ. Stabilization of the prostate-specific tumor suppressor NKX3.1 by the oncogenic protein kinase Pim-1 in prostate cancer cells. J Cell Biochem. 2013 May;114(5):1050-7.
CAS Number: 1353858-99-7
Molecular Weight: 516.42
Compound Purity: 99.23
Research Area: Cancer
Solubility: DMSO : 25 mg/mL (ultrasonic)/H2O : 7.14 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Pim
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