cyclo(CLLFVY), CAS 1446322-73-1

Description: Cyclo(CLLFVY) is an inhibitor of hypoxia-inducible factor-1 (HIF-1), exhibiting half-maximal inhibitory concentrations (IC50) of 19 μM in U2OS cells and 16 μM in MCF-7 cells. It binds to the PAS-B domain of HIF-1α, inhibiting the dimerization and transcriptional activity of HIF-1. Moreover, cyclo(CLLFVY) downregulates the expression of hypoxia response genes (such as VEGF and CAIX), demonstrating antitumor effects against HIF-1-related cancers.

CAS Number: 1446322-73-1

Formula: C38H54N6O7S

Molecular Weight: 738,94

• SKU: TGMTP2717-10mg
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: TP2717-10mg
• Package Unit: 10 mg
• Quantity Unit: STK