Target Synonym: CST 6;Cystatin 6;Cystatin E;Cystatin E/M;Cystatin M;Cystatin M/E;Cystatin6;Cystatin-6;CystatinE;Cystatin-E;CystatinM;Cystatin-M;Cysteine proteinase inhibitor;CYTM;CST6
Background: Cystatin E/M, also referred to as CST6, is a member of type 2 cysteine proteinase inhibitors of the cystatin superfamily, and inhibits papain and cathepsin B. Cystatin E is a low molecular mass secreted protein existing in both a glycosylated (17 kDa) and an unglycosylated (14 kDa) form, with two characteristic intrachain disulfide bridges. Expression of cystatin M/E is found to be restricted to the epidermis, more specifically in the stratum granulosum, sweat glands, sebaceous glands, and the hair follicles. In addition to its function as a cysteine protease inhibitor, cystatin M/E also serves as a target for cross-linking by transglutaminases. Accordingly, cystatin M/E was suggested to be involved in barrier formation and maintenance. Furthermore, studies have revealed that cystatin M/E is frequently epigenetically inactivated during breast carcinogenesis, and thus be regarded as a candidate of tumour suppressor gene.
Immunogen: Recombinant Human Cystatin E / CST6 protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: IHC-P 1:50-1:200;
English
Deutsch
