Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester
Purity: ≥95%
Formula Markup: C18H26O5
Formula Weight: 322.4
CAS Number: 321661-62-5
Notes: Cytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM).{28698} Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself.{28698} Signaling through Nur77 induces apoptosis in cancer cells and retards xenograft tumor growth.{28698} It also induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat and high cholesterol diet.{28698,28695} Cytosporone B is brain penetrant and aggravates early brain injury in rats when given (13 mg/kg intraperitoneally) after experimentally-induced subarachnoid hemorrhage.{28694} Cytosporone B also has antibacterial properties.{28693,28696}
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