Product Description: CZC-8004 (CZC-00008004), an aminopyrimidine, is a pan-kinase inhibitor. CZC-8004 can bind a range of tyrosine kinases, including EGFR and VEGFR2 with IC50 values of 650 and 437 nM, respectively.CZC-8004 has antitumor activity[1][2][3].
Applications: Cancer-Kinase/protease
Formula: C17H16FN5
References: [1]Ying ZD, et, al. Integrated in silico-in vitro analysis of systematic kinase gatekeeper mutation effects on pan-kinase inhibitors in targeted liver cancer therapy. J Chin Chem Soc. 2020 Oct 29;1-10./[2]Deane FM, et, al. FD5180, a Novel Protein Kinase Affinity Probe, and the Effect of Bead Loading on Protein Kinase Identification. ACS Omega. 2017 Jul 31;2(7):3828-3838./[3]Klutchko SR, et al. 2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity. J Med Chem. 1998 Aug 13;41(17):3276-92.
CAS Number: 916603-07-1
Molecular Weight: 309.34
Compound Purity: 99.81
Research Area: Cancer
Solubility: DMSO : 77.5 mg/mL (ultrasonic)
Target: EGFR;VEGFR
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