Product Description: D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C3H7NO3
References: [1]Andrea R. Durrant, et al. D-Serine in Neuropsychiatric Disorders: New Advances./[2]MacKay MB, et al. D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression? Front Psychiatry. 2019 Feb 6;10:25./[3]Dai X, et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986./[4]Suwandhi L, et al. Chronic d-serine supplementation impairs insulin secretion. Mol Metab. 2018 Oct;16:191-202.
CAS Number: 312-84-5
Molecular Weight: 105.09
Compound Purity: 98.0
Research Area: Neurological Disease
Solubility: H2O : ≥ 50 mg/mL/Methanol : < 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Endogenous Metabolite;iGluR
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