Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: O-(octahydro-4,7-methano-1H-inden-5-yl) ester, carbonodithioic acid, monopotassium salt
Purity: ≥90%
Formula Markup: C11H15OS2 / K
Formula Weight: 266.5
CAS Number: 83373-60-8
Notes: D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC; Ki = 6.4 µM).{26211} It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D.{26213} D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively.{26214} Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities.{26213} In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC50 = 20 µg/ml) and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells.{26212,3364}
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