Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 4-fluoro-1,3-dihydro-2H-isoindole-2-carboxylic acid, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]- 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e] pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester
Purity: ≥95%
Formula Markup: C35H46FN5O9S
Formula Weight: 731.832443
CAS Number: 850876-88-9
Notes: Danoprevir is an orally bioavailable inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A; IC50 = 1 nM), a serine protease essential for HCV replication.{40947} It is selective for NS3/4A over a panel of 53 proteases at a concentration of 10 μM. Danoprevir inhibits replication of the HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s = 0.2-0.4 nM) as well as 2b and 3a (IC50s = 1.6 and 3.5 nM, respectively) in vitro. It also reduces the number of HCV genotype 1b replicons in Huh-7 cells (EC50 = 1.8 nM).
English
Deutsch
