Dapagliflozin, CAS 461432-26-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol

Purity: ≥98%

Formula Markup: C21H25ClO6

Formula Weight: 408.9

CAS Number: 461432-26-8

Notes: Dapagliflozin is an inhibitor of sodium-glucose transporter 2 (SGLT2; IC50s = 1.12 and 3 nM for the human and rat enzymes, respectively).{22762} It is selective for SGLT2 over SGLT1 (IC50s = 1,391 and 620 nM for the human and rat enzymes, respectively) and human adipocyte glucose transporter (GLUT) activity at 20 µM. Dapagliflozin (0.1 and 1 mg/kg) increases urinary glucose levels in normal and Zucker diabetic rats. It decreases fasting and fed plasma glucose levels in Zucker diabetic rats when administered at doses of 0.01, 0.1, and 1 mg/kg.

• SKU: CAY11574-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 11574-5
• Package Unit: 5 mg
• Quantity Unit: STK