DASA-58, CAS 1203494-49-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 3-[[4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]-benzenamine

Purity: ≥98%

Formula Markup: C19H23N3O6S2

Formula Weight: 453.5

CAS Number: 1203494-49-8

Notes: DASA-58 is a selective activator of pyruvate kinase M2 (PKM2; AC50 = 38 nM in vitro, EC50 = 19.6 µM in cells).{21504} DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated proteins.{21504} Through its effects on PKM2, DASA-58 blocks the induction of HIF-1α by lipopolysaccharide in bone marrow-derived macrophages, suppressing the expression of several HIF-1α-dependent targets, including IL-1β.{31878} It also impairs metastatic dissemination of prostate cancer PCa cells in SCID mice.{31877}

• SKU: CAY13941-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 13941-1
• Package Unit: 1 mg
• Quantity Unit: STK