DBeQ, CAS 177355-84-9

Product Description: DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively; DBeQ also inhibits Vps4 with an IC50 of 11.5 μM.

Applications: Cancer-programmed cell death

Formula: C22H20N4

References: [1]Chou TF, et al.Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9./[2]Zhang Y, et al. The AAA ATPase Vps4 Plays Important Roles in Candida albicans Hyphal Formation and is Inhibited by DBeQ. Mycopathologia. 2016 Jun;181(5-6):329-39.

CAS Number: 177355-84-9

Molecular Weight: 340.42

Compound Purity: 99.68

Research Area: Cancer

Solubility: DMSO : 35.71 mg/mL (ultrasonic)

Target: Apoptosis;Autophagy;p97

• SKU: MEXHY-15945-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-15945-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK