Product Description: Deacylketoconazole (N-Deacetylketoconazole; R-39519) is an orally active metabolite of Ketoconazole (HY-B0105). Deacylketoconazole exhibits antifungal and antibacterial activity. Deacylketoconazole is cytotoxic in rats hepatocyte[1][2][3].
Applications: COVID-19-immunoregulation
Formula: C24H26Cl2N4O3
References: [1]Pfaller MA, et al., Activity of ketoconazole and its deacyl derivative against Plasmodium falciparum and Candida isolates. Antimicrob Agents Chemother. 1982 Nov;22(5):917-9./[2]Bossche H V, et al., Molecular basis for the antimycotic and antibacterial activity of N‐substituted imidazoles and triazoles: The inhibition of isoprenoid biosynthesis[J]. Pesticide science, 1984, 15(2): 188-198./[3]Fukami T, et al., Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity. Biochem Pharmacol. 2016 Sep 15;116:153-61.
CAS Number: 67914-61-8
Molecular Weight: 489.39
Compound Purity: 99.60
Research Area: Infection
Solubility: DMSO : 2.5 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Bacterial;Fungal
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