Debio 0123 (hydrochloride)

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]-pyrimido[4,5-d]pyrimidin-4(1H)-one, hydrochloride

Purity: ≥98%

Formula Markup: C26H28Cl2N6O / XHCl

Formula Weight: 511.44576

Notes: Debio 0123 is an inhibitor of the checkpoint kinase WEE1 (IC50 = 0.8 nM).{69899} In vivo, debio 0123 (30 mg/kg per day), in combination with the inhibitor of topoisomerase II etoposide (Item No. 12092), reduces tumor volume in a patient-derived xenograft (PDX) mouse model of stomach cancer.{69900}

• SKU: CAY39674-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39674-5
• Package Unit: 5 mg
• Quantity Unit: STK