Product Description: DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM.
Applications: Cancer-programmed cell death
Formula: C20H22BrCl2N3
References: [1]Lieber S, et al. (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties. J Med Chem. 2012 Mar 22;55(6):2858-68./[2]Lieber S, et al. The inverse agonist DG172 triggers a PPARβ/δ-independent myeloid lineage shift and promotes GM-CSF/IL-4-induced dendritic cell differentiation. Mol Pharmacol. 2015 Feb;87(2):162-73./[3]Yao PL, et al. Peroxisome Proliferator-activated Receptor-D (PPARD) Coordinates Mouse Spermatogenesis by Modulating Extracellular Signal-regulated Kinase (ERK)-dependent Signaling. J Biol Chem. 2015 Sep 18;290(38):23416-31.
CAS Number: 1361504-77-9
Molecular Weight: 455.22
Compound Purity: 99.35
Research Area: Cancer
Solubility: 10 mM in DMSO/H2O : 14.29 mg/mL (ultrasonic)
Target: PPAR
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