DGM, CAS 162401-62-9

Product Description: DGM is an inhibitor of the TGF-β1/Smad signaling pathway with significant antifibrotic effects. DGM inhibits the epithelial-mesenchymal transition (EMT) process in alveolar epithelial cells and slows the progression of pulmonary fibrosis in vivo by reducing lung inflammation, improving lung function, and decreasing extracellular matrix (ECM) remodeling. DGM can be used in research on idiopathic pulmonary fibrosis (IPF) and EMT-related diseases[1].

Formula: C12H12F2O4

References: [1]Sun T, et al. Inhibitory Effects of 3-Cyclopropylmethoxy-4-(difluoromethoxy) Benzoic Acid on TGF-β1-Induced Epithelial-Mesenchymal Transformation of In Vitro and Bleomycin-Induced Pulmonary Fibrosis In Vivo. Int J Mol Sci. 2023 Mar 24;24(7):6172.

CAS Number: 162401-62-9

Molecular Weight: 258.22

Compound Purity: 99.99

Research Area: Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: TGF-beta/Smad

• SKU: MEXHY-W005379-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-W005379-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK