Product Description: DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of true black pigment, and it’s also a moderately potent GPR35 agonist. DHICA shows an ability to stimulate β-arrestin translocation signaling with an EC50 value of 23.2 μM in the U2OS cell line. DHICA plays a significant role in promoting and protecting against DNA damage[1][2].
Formula: C9H7NO4
References: [1]Huayun Deng, et al. Synthesis and Agonistic Activity at the GPR35 of 5,6-Dihydroxyindole-2-carboxylic Acid Analogues. ACS Med Chem Lett. 2012 Jun 6;3(7):550-4./[2]Maria Carolina Pellosi, et al. Effects of the melanin precursor 5,6-dihydroxy-indole-2-carboxylic acid (DHICA) on DNA damage and repair in the presence of reactive oxygen species. Arch Biochem Biophys. 2014 Sep 1:557:55-64.
CAS Number: 4790-08-3
Molecular Weight: 193.16
Compound Purity: 97.0
Research Area: Others
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Arrestin;Endogenous Metabolite;GPR35
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