Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2E-butenedioic acid, 1,4-dimethyl ester
Purity: ≥95%
Formula Markup: C6H8O4
Formula Weight: 144.1
CAS Number: 624-49-7
Notes: Dimethyl fumarate is a lipophilic electrophile that has profound effects on oxidative and immunological pathways.{23442} It rapidly interacts in a Michael addition reaction with glutathione or is metabolized to monomethyl fumarate.{23442} Dimethyl fumarate at low micromolar levels activates the nuclear factor erythroid 2-related factor 2 (Nrf2), resulting in an antioxidant response featuring heme oxygenase-1 expression and increased glutathione levels.{23442} It also suppresses the expression of pro-inflammatory cytokines and inhibits angiogenesis.{23440,23439} Through these actions dimethyl fumarate alters the course of psoriasis and may reduce inflammation related to multiple sclerosis.{23440,23441}
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