Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-naphtho[2,3-c]furan-1(3H)-one
Purity: ≥98%
Formula Markup: C21H16O7
Formula Weight: 380.4
CAS Number: 22055-22-7
Notes: Diphyllin is a lignan that has been found in C. collinus and has diverse biological activities.{62484,35812,62483} It reduces viral titers in Vero cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC50 = 1.92 µM).{62484} It inhibits bovine chromaffin granule V-ATPase (IC50 = 17 nM) and lysosomal acidification in primary human osteoclasts.{35812} Diphyllin (1, 5, and 10 µM) induces apoptosis in and inhibits the growth of SGC-7901 gastric adenocarcinoma cells.{62483} In vivo, diphyllin (20 mg/kg) reduces intratumoral expression of V-ATPase and tumor volume in an SGC-7901 mouse xenograft model.
English
Deutsch
