Dipraglurant, CAS 872363-17-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 6-fluoro-2-[4-(2-pyridinyl)-3-butyn-1-yl]-imidazo[1,2-a]pyridine

Purity: ≥98%

Formula Markup: C16H12FN3

Formula Weight: 265.285103

CAS Number: 872363-17-2

Notes: A negative allosteric modulator of mGluR5 (Ki = 21 nM); inhibits glutamate-induced calcium mobilization, IP1 accumulation, and ERK1/2 phosphorylation in HEK293A cells expressing rat mGluR5a (pKBs = 5.83, 6.5, and 6.67, respectively); increases drinking in the Vogel punished drinking task in rats, indicating anxiolytic-like activity, decreases marble burying in mice, and reduces immobility time in the forced swim test in mice (ED50s = 7.4, 43, and ~30 mg/kg, respectively); reduces chorea and dystonia scores in a macaque model of MPTP-induced PD-LID

• SKU: CAY42535-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42535-1
• Package Unit: 1 mg
• Quantity Unit: STK