Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 6,7-dihydrodipyrido[1,2-a:2',1'-c]pyrazine-5,8-diium-1,2,3,4,6,6,7,7,9,10,11,12-d12, dibromide
Purity: ≥99% deuterated forms (d1-d12)
Formula Markup: C12D12N2 / 2Br
Formula Weight: 356.11788
Notes: Diquat-d12 is intended for use as an internal standard for the quantification of diquat (Item No. 26251) by GC- or LC-MS. Diquat is a bipyridylium herbicide that, as a stable radical, acts as an electron acceptor in the electron transport chain and is reoxidized by molecular oxygen, producing reactive oxygen species (ROS).{37559} Diquat administration has been used to induce oxidative stress in vitro and in animal models.{37560,37561,37562} It increases the production of ROS and decreases the mitochondrial membrane potential in mitochondria isolated from porcine intestine leading to mitophagy when administered at a dose of 100 mg/kg.{37560} Formulations containing diquat have been used in agriculture for crop desiccation and defoliation.
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