Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 4-[6-[4-(1-methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
Purity: ≥98%
Formula Markup: C24H20N4O
Formula Weight: 380.4
CAS Number: 1206711-16-1
Notes: Bone morphogenetic proteins (BMP) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation.{23503} DMH1 is an analog of the non-selective BMP receptor inhibitor dorsomorphin (Item No. 11967) that potently inhibits the kinase activity of activin receptor-like kinase 2 (ALK2; IC50 = 13-108 nM).{28912,28826} It is much less effective at ALK4, ALK5, AMPK, KDR (VEGFR2) or PDGFRβ, although it inhibits ALK1 and ALK3 at nanomolar concentrations.{28912,28826} DMH1 is effective in vivo, as it disrupts dorsoventral development in zebrafish.{28912} It also affects stem cell development, increasing cardiomyocyte progenitors and promoting neurogenesis.{28911,28914} DMH1 inhibits the growth of lung cancer cells, reducing tumor growth in a xenograft mouse model.{28913}
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