DNA-PK-IN-8, CAS 2823369-81-7

Product Description: DNA-PK-IN-8 is a highly potent, selective and orally active DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of 0.8 nM. DNA-PK-IN-8 exhibits synergistic antiproliferative activity against a series of cancer cell lines and significantly suppresses HL-60 tumor growth, when using in combination with Doxorubicin[1].

Applications: Cancer-Kinase/protease

Formula: C19H22N8O2

References: [1]Ding Z, et al. Discovery of novel 7,8-dihydropteridine-6(5H)-one-based DNA-PK inhibitors as potential anticancer agents via scaffold hopping strategy. Eur J Med Chem. 2022;237:114401.

CAS Number: 2823369-81-7

Molecular Weight: 394.43

Compound Purity: 99.74

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: DNA-PK

• SKU: MEXHY-146565-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-146565-1
• Package Unit: 1 mg
• Quantity Unit: STK