Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1-[4-[2-hydroxy-3-(5-quinolinyloxy)propyl]-1-piperazinyl]-2,2-diphenyl-ethanone
Purity: ≥98%
Formula Markup: C30H31N3O3
Formula Weight: 481.58556
CAS Number: 129716-58-1
Notes: Dofequidar is a quinoline derivative and inhibitor of multidrug resistance.{53975,53976} It inhibits P-glycoprotein in a photolabeling assay when used at a concentration of 100 μM.{53975} Dofequidar (10 μM) increases intracellular accumulation of [3H]-vincristine in HL-60R cells endogenously expressing the gene encoding multidrug resistance-associated protein (MRP).{53976} It restores susceptibility to vincristine- or doxorubicin-induced cytotoxicity in vincristine-resistant P388, vincristine-resistant K562, and doxorubicin-resistant K562 cells in a concentration-dependent manner.{53975} Dofequidar (80 mg/kg twice per day) increases survival in a vincristine-resistant P388 murine leukemia model compared with untreated controls when administered in combination with vincristine (Item No. 11764).
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