Dofetilide, CAS 115256-11-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide

Purity: ≥98%

Formula Markup: C19H27N3O5S2

Formula Weight: 441.6

CAS Number: 115256-11-6

Notes: Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}

• SKU: CAY15045-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 15045-10
• Package Unit: 10 mg
• Quantity Unit: STK