Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2,3-dihydro-5,6-dimethoxy-2[[1-(phenylmethyl-d2)-4-piperidinyl]methyl-d2]-1H-inden-1-one, monohydrochloride
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C24H25D4NO3 / HCl
Formula Weight: 420.0
CAS Number: 1219798-88-5
Notes: Donepezil-d4 is intended for use as an internal standard for the quantification of donepezil (Item No. 13245) by GC- or LC-MS. Donepezil is an inhibitor of acetylcholinesterase (AChE; IC50 = 6.7 nM).{58815} It is selective for AChE over butyrylcholinesterase (BChE; IC50 = 988 nM). Donepezil (0.1 and 1 µM) inhibits the production of nitric oxide (NO) and TNF-α induced by oligomeric amyloid-β (1-42) (AβO1-42) in primary rat microglial cells.{58816} It increases ACh levels in the cortex and hippocampus of aged rats when administered at a dose of 1.5 mg/kg.{58817} Donepezil (2 mg/kg) reduces Mac-1 and GFAP protein expression, markers of microglia and astrocyte activation, respectively, in the hippocampal dentate gyrus of a mouse model of Alzheimer’s disease induced by intrahippocampal injection of AβO1-42.{58816} It increases step-through latency in a passive avoidance test in the same model. Formulations containing donepezil have been used in the treatment of Alzheimer’s disease.
English
Deutsch
