Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (8S,10S)-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
Purity: ≥98%
Formula Markup: C21H18O9
Formula Weight: 414.4
CAS Number: 24385-10-2
Notes: Doxorubicinone is a metabolite of the anthracycline antitumor antibiotic doxorubicin (Item No. 15007).{22647,37770} Doxorubicinone inhibits mitochondrial succinoxidase from bovine heart and reduces the mitochondrial inner membrane potential in rat heart and liver mitochondria in a concentration-dependent manner.{37771,37772} Doxorubicinone (40 μM) increases pentose phosphate pathway flux by 45% and reduces activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD) by 17 and 60%, respectively, in human erythrocytes.{37773} It also induces cytotoxicity in patient-derived ovarian cancer colonies in a concentration-dependent manner.{37770}
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