Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-(6-methyl-d)-1,11-dioxo-2-naphthacene-4,6-d2-carboxamide, hydrochloride, compd. with ethanol, hydrate (2:2:1:X)
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: 2[C22H21D3N2O8] / 2HCl / XH2O / C2H6O
Formula Weight: 894.9
Notes: Doxycycline-d3 is intended for use as an internal standard for the quantification of doxycycline (Item No. 14422) by GC- or LC-MS. Doxycycline is a broad-spectrum tetracycline antibiotic.{42890,22938} It inhibits bacterial protein synthesis by binding to ribosomes.{22938,42891} Doxycycline also selectively inhibits human matrix metalloproteinase-8 (MMP-8) and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, when used at a concentration of 30 μM.{22936} It can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or absence (Tet-Off) of doxycycline.{22932,22934} Formulations containing doxycycline have been used in the treatment of bacterial infections and the prevention of malaria.
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