Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[2-butyl-3-[4-[3-(dibutylamino)propoxy-1,1,2,2,3,3-d6]benzoyl]-5-benzofuranyl]-methanesulfonamide, monohydrochloride
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C31H38D6N2O5S / HCl
Formula Weight: 599.25454
CAS Number: 1329809-23-5
Notes: Dronedarone-d6 is intended for use as an internal standard for the quantification of dronedarone (Item No. 9000543) by GC- or LC-MS. Dronedarone is an antiarrhythmic agent and a derivative of amiodarone (Item No. 15213).{41032,41033} It inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol (carbamoylcholine; Item No. 14486) or intracellular loading of GTPγS in single cells isolated from guinea pig atria (IC50s = 0.1 and 1 µM, respectively).{41033} Dronedarone (50 and 100 mg/kg) reduces sinus frequency and prolongs action potential duration (APD) in isolated rabbit ventricular myocardium. It increases atrial APD and the atrial effective refractory period (AERP) in a dog model of atrial fibrillation induced by rapid right atrial pacing.{57286} Formulations containing dronedarone have been used in the treatment of atrial fibrillation.
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